C9ORF72 anticorps (Internal Region)
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- Antigène Voir toutes C9ORF72 Anticorps
- C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))
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Épitope
- Internal Region
- Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp C9ORF72 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- C9orf72 Antibody detects endogenous levels of total C9orf72.
- Homologie
- Pig,Sheep,Rabbit
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human C9orf72, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product C9ORF72 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- C9ORF72 (Chromosome 9 Open Reading Frame 72 (C9ORF72))
- Autre désignation
- C9orf72 (C9ORF72 Produits)
- Synonymes
- anticorps CZH9orf72, anticorps ALSFTD, anticorps FTDALS, anticorps AI840585, anticorps c9orf72, anticorps chromosome Z C9orf72 homolog, anticorps chromosome 9 open reading frame 72, anticorps RIKEN cDNA 3110043O21 gene, anticorps similar to RIKEN cDNA 3110043O21, anticorps chromosome 9 open reading frame 72 L homeolog, anticorps CZH9orf72, anticorps C9orf72, anticorps 3110043O21Rik, anticorps RGD1359108, anticorps c9orf72.L
- Sujet
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Description: Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy (PubMed:27193190, PubMed:27103069, PubMed:27617292, PubMed:28195531). In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (PubMed:27103069). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kinase activity (PubMed:27617292). Positively regulates initiation of autophagy by regulating the RAB1A-dependent trafficking of the ATG1/ULK1 kinase complex to the phagophore which leads to autophagosome formation (PubMed:27334615). Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates (PubMed:27559131). Plays a role in endosomal trafficking (PubMed:24549040). May be involved in regulating the maturation of phagosomes to lysosomes (By similarity). Regulates actin dynamics in motor neurons by inhibiting the GTP-binding activity of ARF6, leading to ARF6 inactivation (PubMed:27723745). This reduces the activity of the LIMK1 and LIMK2 kinases which are responsible for phosphorylation and inactivation of cofilin, leading to cofilin activation (PubMed:27723745). Positively regulates axon extension and axon growth cone size in spinal motor neurons (PubMed:27723745). Plays a role within the hematopoietic system in restricting inflammation and the development of autoimmunity (By similarity).
Gene: C9orf72
- Poids moléculaire
- 50-54 kDa,25-30 kDa
- ID gène
- 203228
- UniProt
- Q96LT7
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