CADM1 anticorps (Internal Region)

N° du produit ABIN6260400

Détail du produit anti-CADM1 anticorps

Antigène: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CADM1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CADM1 Antibody detects endogenous levels of total CADM1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CADM1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CADM1

Antigène: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Autre désignation: CADM1 (CADM1 Produits)

Synonymes: anticorps BL2, anticorps IGSF4, anticorps IGSF4A, anticorps NECL2, anticorps Necl-2, anticorps RA175, anticorps ST17, anticorps SYNCAM, anticorps TSLC1, anticorps sTSLC-1, anticorps sgIGSF, anticorps synCAM1, anticorps bl2, anticorps igsf4, anticorps igsf4a, anticorps necl-2, anticorps necl2, anticorps ra175, anticorps sgigsf, anticorps st17, anticorps stslc-1, anticorps syncam, anticorps syncam1, anticorps tslc1, anticorps xnecl2, anticorps 2900073G06Rik, anticorps 3100001I08Rik, anticorps AI987920, anticorps Bl2, anticorps Igsf4, anticorps Igsf4a, anticorps Necl2, anticorps RA175A, anticorps RA175B, anticorps RA175C, anticorps RA175N, anticorps SgIGSF, anticorps SynCam, anticorps Tslc1, anticorps SynCAM1, anticorps cell adhesion molecule 1, anticorps cell adhesion molecule 1 L homeolog, anticorps CADM1, anticorps cadm1.L, anticorps Cadm1

Sujet:

Description: Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Gene: CADM1

Poids moléculaire: 49kDa

ID gène: 23705

UniProt: Q9BY67

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation