CALCOCO2 anticorps (Internal Region)

N° du produit ABIN6260408

Détail du produit anti-CALCOCO2 anticorps

Antigène: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CALCOCO2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Specificité: CALCOCO2 Antibody detects endogenous levels of total CALCOCO2.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CALCOCO2, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CALCOCO2

Antigène: CALCOCO2 (Calcium Binding and Coiled-Coil Domain 2 (CALCOCO2))

Autre désignation: CALCOCO2 (CALCOCO2 Produits)

Synonymes: anticorps CALCOCO2, anticorps MGC110205, anticorps wu:fj08c01, anticorps zgc:110205, anticorps DKFZp469D2219, anticorps NDP52, anticorps 2410154J16Rik, anticorps C77254, anticorps Ndp52, anticorps Ndp52l1, anticorps RGD1559974, anticorps calcium binding and coiled-coil domain 2, anticorps CALCOCO2, anticorps calcoco2, anticorps Calcoco2

Sujet:

Description: Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C (PubMed:23022382, PubMed:25771791). May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion (PubMed:17635994).

Gene: CALCOCO2

Poids moléculaire: 52 kDa

ID gène: 10241

UniProt: Q13137