CDK3 anticorps (C-Term)

N° du produit ABIN6260712

Détail du produit anti-CDK3 anticorps

Antigène: CDK3 (Cyclin-Dependent Kinase 3 (CDK3))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CDK3 Antibody detects endogenous levels of total CDK3.

Homologie: Pig,Bovine,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CDK3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-CDK3 (ABIN6260712)

Wang, Xi, Sun, Zhang, Jiang, He, Li: "CDK3 is a major target of miR-150 in cell proliferation and anti-cancer effect." dans: Experimental and molecular pathology, Vol. 102, Issue 2, pp. 181-190, (2017) (PubMed).

Détails sur CDK3

Antigène: CDK3 (Cyclin-Dependent Kinase 3 (CDK3))

Autre désignation: CDK3 (CDK3 Produits)

Synonymes: anticorps 2310050O10Rik, anticorps Cdk3, anticorps cyclin dependent kinase 3, anticorps cyclin-dependent kinase 3, anticorps cyclin-dependent kinase 3, pseudogene, anticorps CDK3, anticorps cgd3_1510, anticorps Chro.30182, anticorps Cdk3-ps

Sujet:

Description: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle, involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Gene: CDK3

Poids moléculaire: 35 kDa

ID gène: 1018

UniProt: Q00526

Pathways: Cycle Cellulaire