CHCHD4 anticorps (N-Term)

N° du produit ABIN6260791

Détail du produit anti-CHCHD4 anticorps

Antigène: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHCHD4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: CHCHD4 Antibody detects endogenous levels of total CHCHD4.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CHCHD4, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CHCHD4

Antigène: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Autre désignation: CHCHD4 (CHCHD4 Produits)

Synonymes: anticorps 2410012P20Rik, anticorps 2810014D17Rik, anticorps AI838740, anticorps MIA40, anticorps TIMM40, anticorps mia40, anticorps timm40, anticorps chchd4, anticorps chchd4a, anticorps fc10g04, anticorps wu:fc10g04, anticorps zgc:100849, anticorps si:dkey-202e22.1, anticorps chchd4b, anticorps CaO19.2977, anticorps coiled-coil-helix-coiled-coil-helix domain containing 4, anticorps coiled-coil-helix-coiled-coil-helix domain containing 4 L homeolog, anticorps coiled-coil-helix-coiled-coil-helix domain containing 4a, anticorps coiled-coil-helix-coiled-coil-helix domain containing 4 S homeolog, anticorps Mia40p, anticorps Chchd4, anticorps CHCHD4, anticorps chchd4, anticorps chchd4.L, anticorps chchd4a, anticorps chchd4.S, anticorps LOC100361898, anticorps MIA40

Sujet:

Description: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19 and MICU1 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364, PubMed:23676665). Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946, PubMed:23676665). Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system (PubMed:23186364). Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864).

Gene: CHCHD4

Poids moléculaire: 22 kDa

ID gène: 131474

UniProt: Q8N4Q1