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CHD5 anticorps (Internal Region)

CHD5 Reactivité: Humain ELISA, WB, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6260796
  • Antigène Voir toutes CHD5 Anticorps
    CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
    Épitope
    • 5
    • 3
    • 2
    • 1
    • 1
    Internal Region
    Reactivité
    • 19
    • 3
    • 1
    Humain
    Hôte
    • 17
    • 1
    • 1
    Lapin
    Clonalité
    • 18
    • 1
    Polyclonal
    Conjugué
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CHD5 est non-conjugé
    Application
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    CHD5 Antibody detects endogenous levels of total CHD5.
    Homologie
    Pig,Bovine,Horse,Sheep,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human CHD5, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CHD5 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IF/ICC 1:200-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    CHD5 (Chromodomain Helicase DNA Binding Protein 5 (CHD5))
    Autre désignation
    CHD5 (CHD5 Produits)
    Synonymes
    anticorps CHD-5, anticorps 4930532L22Rik, anticorps AW060752, anticorps B230399N07Rik, anticorps CHD5, anticorps chromodomain helicase DNA binding protein 5, anticorps potassium voltage-gated channel subfamily A regulatory beta subunit 2, anticorps CHD5, anticorps Chd5, anticorps chd5, anticorps KCNAB2
    Sujet

    Description: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa.

    Gene: CHD5

    Poids moléculaire
    223 kDa
    ID gène
    26038
    UniProt
    Q8TDI0
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