CHMP2A anticorps (Internal Region)

N° du produit ABIN6260811

Détail du produit anti-CHMP2A anticorps

Antigène: CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))

Épitope: Internal Region

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP2A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: CHMP2A Antibody detects endogenous levels of total CHMP2A.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human CHMP2A, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur CHMP2A

Antigène: CHMP2A (Charged Multivesicular Body Protein 2A (CHMP2A))

Autre désignation: CHMP2A (CHMP2A Produits)

Synonymes: anticorps BC-2, anticorps BC2, anticorps CHMP2, anticorps VPS2, anticorps VPS2A, anticorps 1500016L11Rik, anticorps RGD1305050, anticorps bc-2, anticorps bc2, anticorps chmp2, anticorps vps2, anticorps vps2a, anticorps fj10d05, anticorps wu:fi18h03, anticorps wu:fj10d05, anticorps zgc:55361, anticorps charged multivesicular body protein 2a, anticorps charged multivesicular body protein 2A, anticorps Charged multivesicular body protein 2a, anticorps charged multivesicular body protein 2A L homeolog, anticorps ATEG_06167, anticorps LOC5570080, anticorps EDI_289610, anticorps PTRG_09933, anticorps NAEGRDRAFT_39042, anticorps PITG_17335, anticorps Tsp_00033, anticorps LOC100284170, anticorps LOC100284688, anticorps chm2a, anticorps chmp2a, anticorps CHMP2A, anticorps Chmp2a, anticorps chmp2a.L

Sujet:

Description: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.

Gene: CHMP2A

Poids moléculaire: 32 kDa

ID gène: 27243

UniProt: O43633

Pathways: SARS-CoV-2 Protein Interactome