COPS8 anticorps (Internal Region)

N° du produit ABIN6260973

Détail du produit anti-COPS8 anticorps

Antigène: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Épitope: Internal Region

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS8 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: COPS8 Antibody detects endogenous levels of total COPS8.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human COPS8, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur COPS8

Antigène: COPS8 (COP9 Signalosome Subunit 8 (COPS8))

Autre désignation: COPS8 (COPS8 Produits)

Synonymes: anticorps COP9, anticorps CSN8, anticorps SGN8, anticorps csn8, anticorps cops8, anticorps MGC76051, anticorps MGC80215, anticorps DDBDRAFT_0167123, anticorps DDBDRAFT_0233107, anticorps DDB_0167123, anticorps DDB_0233107, anticorps zgc:56319, anticorps zgc:86840, anticorps MGC86182, anticorps 9430009J09Rik, anticorps AA408242, anticorps Csn8, anticorps Sgn8, anticorps CONSTITUTIVE PHOTOMORPHOGENIC 9, anticorps COP9 SIGNALOSOME SUBUNIT 8, anticorps DL3095C, anticorps EMB143, anticorps EMBRYO DEFECTIVE 143, anticorps FCAALL.131, anticorps FUS7, anticorps FUSCA 7, anticorps FUSCA PROTEIN FUS7, anticorps CG13383, anticorps CG33297, anticorps CG42522, anticorps CH8, anticorps Dch8, anticorps Dmel\\CG42522, anticorps Dmel_CG13383, anticorps l(2)SH1829, anticorps l(2)SH2 1829, anticorps COP9 signalosome subunit 8, anticorps COP9 signalosome subunit 8 S homeolog, anticorps COP9 signalosome complex subunit 8, anticorps COP9 signalosome subunit 8 L homeolog, anticorps COP9 signalosome, subunit CSN8, anticorps COPS8, anticorps Cops8, anticorps cops8, anticorps cops8.S, anticorps CSN8, anticorps csn8, anticorps cops8.L, anticorps COP9

Sujet:

Description: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Gene: COPS8

Poids moléculaire: 23 kDa

ID gène: 10920

UniProt: Q99627

Pathways: Cycle Cellulaire