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Cullin 1 anticorps

CUL1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6261106
  • Antigène Voir toutes Cullin 1 (CUL1) Anticorps
    Cullin 1 (CUL1)
    Reactivité
    • 76
    • 33
    • 28
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 75
    • 1
    Lapin
    Clonalité
    • 67
    • 9
    Polyclonal
    Conjugué
    • 38
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Cullin 1 est non-conjugé
    Application
    • 42
    • 26
    • 15
    • 14
    • 13
    • 13
    • 11
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    CUL1 Antibody detects endogenous levels of total CUL1
     Réactivité croisée
    Humain, Souris, Rat (Rattus)
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human CUL1
    Isotype
    IgG
    Top Product
    Discover our top product CUL1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C.Stable for 12 months from date of receipt
    Date de péremption
    12 months
  • Antigène
    Cullin 1 (CUL1)
    Autre désignation
    CUL1 (CUL1 Produits)
    Synonymes
    anticorps LOC100282292, anticorps Cullin-1, anticorps Cul1, anticorps zgc:55747, anticorps zgc:77500, anticorps wu:fc13a10, anticorps cullin-1, anticorps ATCUL1, anticorps AUXIN RESISTANT 6, anticorps AXR6, anticorps T10P11.26, anticorps T10P11_26, anticorps cullin 1, anticorps cul1, anticorps wu:fi43h07, anticorps wu:fj43a08, anticorps zgc:111899, anticorps zgc:55483, anticorps Cul-1, anticorps cullin 1, anticorps cullin-1, anticorps Cullin 1, anticorps Cullin-1, anticorps cullin 1a, anticorps cullin 1 S homeolog, anticorps cullin 1b, anticorps CUL1, anticorps LOC100282292, anticorps cul1, anticorps ATEG_00491, anticorps EDI_072700, anticorps EDI_264400, anticorps SJAG_02591, anticorps BDBG_03785, anticorps Cul1, anticorps cul1a, anticorps cul1.S, anticorps cul-1, anticorps cul1b
    Sujet

    Description: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25704143, PubMed:25503564). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22', the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2.

    Gene: CUL1

    Poids moléculaire
    90kDa
    ID gène
    8454
    UniProt
    Q13616
    Pathways
    Cycle Cellulaire, Signalisation Hedgehog, Mitotic G1-G1/S Phases, Regulation of Cell Size
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