DAPK3 anticorps (Internal Region)
-
- Antigène Voir toutes DAPK3 Anticorps
- DAPK3 (Death-Associated Protein Kinase 3 (DAPK3))
-
Épitope
- Internal Region
-
Reactivité
- Humain, Souris, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp DAPK3 est non-conjugé
-
Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- ZIP Kinase Antibody detects endogenous levels of total ZIP Kinase.
- Homologie
- Pig,Bovine,Horse,Sheep,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human ZIP Kinase, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product DAPK3 Anticorps primaire
-
-
- Indications d'application
- WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
-
- Antigène
- DAPK3 (Death-Associated Protein Kinase 3 (DAPK3))
- Autre désignation
- DAPK3 (DAPK3 Produits)
- Synonymes
- anticorps DAPK3, anticorps dapk3, anticorps wu:fc25b08, anticorps si:dkey-57k2.5, anticorps MGC114871, anticorps ZIP, anticorps ZIPK, anticorps dlk, anticorps Dapkl, anticorps death associated protein kinase 3, anticorps death-associated protein kinase 3, anticorps death-associated protein kinase 3 L homeolog, anticorps DAPK3, anticorps dapk3, anticorps dapk3.L, anticorps Dapk3
- Sujet
-
Description: Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A, the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca2+ and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.
Gene: DAPK3
- Poids moléculaire
- 53 kDa
- ID gène
- 1613
- UniProt
- O43293
-