DNAJC10 anticorps (C-Term)

N° du produit ABIN6261333

Détail du produit anti-DNAJC10 anticorps

Antigène: DNAJC10 (DnaJ (Hsp40) Homolog, Subfamily C, Member 10 (DNAJC10))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNAJC10 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: DNAJC10 Antibody detects endogenous levels of total DNAJC10.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DNAJC10, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur DNAJC10

Antigène: DNAJC10 (DnaJ (Hsp40) Homolog, Subfamily C, Member 10 (DNAJC10))

Autre désignation: DNAJC10 (DNAJC10 Produits)

Synonymes: anticorps ERdj5, anticorps JPDI, anticorps MTHr, anticorps PDIA19, anticorps 1200006L06Rik, anticorps D2Ertd706e, anticorps dnajc10, anticorps zgc:162218, anticorps DnaJ heat shock protein family (Hsp40) member C10, anticorps DnaJ (Hsp40) homolog, subfamily C, member 10, anticorps DNAJC10, anticorps Dnajc10, anticorps dnajc10

Sujet:

Description: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.

Gene: DNAJC10

Poids moléculaire: 75-80 kDa

ID gène: 54431

UniProt: Q8IXB1

Pathways: Cell RedoxHomeostasis