Dynamin 1-Like anticorps (C-Term)

N° du produit ABIN6261371

Détail du produit anti-Dynamin 1-Like anticorps

Antigène: Dynamin 1-Like (DNM1L)

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dynamin 1-Like est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: DRP1 Antibody detects endogenous levels of total DRP1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DRP1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Dynamin 1-Like

Antigène: Dynamin 1-Like (DNM1L)

Autre désignation: DNM1L (DNM1L Produits)

Synonymes: anticorps DLP1, anticorps DRP1, anticorps DVLP, anticorps DYMPLE, anticorps EMPF, anticorps HDYNIV, anticorps 6330417M19Rik, anticorps AI450666, anticorps Dlp1, anticorps Dnmlp1, anticorps Drp1, anticorps python, anticorps Dnml1, anticorps dnm1l, anticorps MGC53850, anticorps zgc:66163, anticorps DNM1L, anticorps 18.m06247, anticorps CG3210, anticorps DRP, anticorps Dmel\CG3210, anticorps Dnm1/Drp1, anticorps Drp, anticorps Drp-1, anticorps drp-1, anticorps drp1, anticorps frat, anticorps l(2)22Fc, anticorps l(2)22Fd, anticorps l(2)ND2, anticorps l(2)ND3, anticorps dynamin 1 like, anticorps dynamin 1-like, anticorps dynamin 1-like L homeolog, anticorps dynamin-1-like, anticorps dynamin-1-like protein, anticorps dynamin-like protein, anticorps Dynamin related protein 1, anticorps DNM1L, anticorps Dnm1l, anticorps dnm1l.L, anticorps dnm1l, anticorps LOC100369408, anticorps LOC411472, anticorps dyn1, anticorps cgd1_580, anticorps EHI_052740, anticorps PVX_092875, anticorps BBOV_II002980, anticorps Drp1

Sujet:

Description: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis, this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis (PubMed:26992161). Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles, the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.

Gene: DNM1L

Poids moléculaire: 79kDa

ID gène: 10059

UniProt: O00429