SHFM1 anticorps
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- Antigène Voir toutes SHFM1 Anticorps
- SHFM1 (Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1))
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SHFM1 est non-conjugé
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Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Specificité
- DSS1 antibody detects endogenous levels of DSS1.
- Réactivité croisée
- Humain, Rat (Rattus)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human DSS1.
- Isotype
- IgG
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C.Stable for 12 months from date of receipt
- Date de péremption
- 12 months
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- Antigène
- SHFM1 (Split Hand/foot Malformation (Ectrodactyly) Type 1 (SHFM1))
- Autre désignation
- DSS1 (SHFM1 Produits)
- Synonymes
- anticorps DSS1, anticorps ECD, anticorps SEM1, anticorps SHFD1, anticorps SHSF1, anticorps Shfdg1, anticorps Shfg, anticorps Dss1, anticorps SHFM1, anticorps dss1, anticorps ecd, anticorps sem1, anticorps shfd1, anticorps shfdg1, anticorps shfm1, anticorps shfm1.S, anticorps shsf1, anticorps wu:fb55c02, anticorps zgc:56203, anticorps zgc:85901, anticorps SEM1, 26S proteasome complex subunit, anticorps SEM1, 26S proteasome complex subunit S homeolog, anticorps SEM1, anticorps Sem1, anticorps sem1.S, anticorps sem1
- Sujet
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Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.
Gene: SEM1
- Poids moléculaire
- 8-10 kDa
- ID gène
- 7979
- UniProt
- P60896
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