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DTNBP1 anticorps (C-Term)

DTNBP1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6261377
  • Antigène Voir toutes DTNBP1 Anticorps
    DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))
    Épitope
    • 15
    • 8
    • 8
    • 7
    • 7
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 58
    • 27
    • 26
    • 15
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 88
    • 2
    Lapin
    Clonalité
    • 88
    • 2
    Polyclonal
    Conjugué
    • 26
    • 9
    • 9
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp DTNBP1 est non-conjugé
    Application
    • 46
    • 42
    • 29
    • 26
    • 26
    • 11
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificité
    DTNBP1 Antibody detects endogenous levels of total DTNBP1.
    Homologie
    Bovine,Horse
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human DTNBP1, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product DTNBP1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))
    Autre désignation
    DTNBP1 (DTNBP1 Produits)
    Synonymes
    anticorps 5430437B18Rik, anticorps AW048963, anticorps Bloc1s8, anticorps dysbindin, anticorps sdy, anticorps BLOC1S8, anticorps DBND, anticorps HPS7, anticorps My031, anticorps SDY, anticorps dtnbp1, anticorps zgc:56462, anticorps MGC83903, anticorps dbnd, anticorps hps7, anticorps my031, anticorps MGC85477, anticorps DTNBP1, anticorps CG6856, anticorps Ddysb, anticorps Dmel\\CG6856, anticorps si:ch211-285p6.1, anticorps dystrobrevin binding protein 1, anticorps Dysbindin, anticorps dystrobrevin binding protein 1a, anticorps dystrobrevin binding protein 1 L homeolog, anticorps dystrobrevin binding protein 1 S homeolog, anticorps dystrobrevin binding protein 1b, anticorps Dtnbp1, anticorps DTNBP1, anticorps dtbp1, anticorps dtnbp1a, anticorps dtnbp1.L, anticorps dtnbp1.S, anticorps dtnbp1, anticorps Dysb, anticorps dtnbp1b
    Sujet

    Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.

    Gene: DTNBP1

    Poids moléculaire
    39kDa
    ID gène
    84062
    UniProt
    Q96EV8
    Pathways
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling
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