EIF3A anticorps (C-Term)

N° du produit ABIN6261480

Détail du produit anti-EIF3A anticorps

Antigène: EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF3A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: EIF3A Antibody detects endogenous levels of total EIF3A.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human EIF3A, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur EIF3A

Antigène: EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A (EIF3A))

Autre désignation: EIF3A (EIF3A Produits)

Synonymes: anticorps EIF3, anticorps EIF3S10, anticorps P167, anticorps TIF32, anticorps eIF3-p170, anticorps eIF3-theta, anticorps p180, anticorps p185, anticorps EIF6, anticorps A830012B05Rik, anticorps Csma, anticorps Eif3, anticorps Eif3s10, anticorps mKIAA0139, anticorps ZH12, anticorps eif3s10, anticorps eIF3 p110, anticorps eIF3a, anticorps eukaryotic translation initiation factor 3 subunit A, anticorps eukaryotic translation initiation factor 3, subunit A, anticorps eukaryotic translation initiation factor 3 subunit A S homeolog, anticorps translation initiation factor eIF3a, anticorps EIF3A, anticorps Eif3a, anticorps eif3a.S, anticorps tif32

Sujet:

Description: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).

Gene: EIF3A

Poids moléculaire: 167kDa

ID gène: 8661

UniProt: Q14152

Pathways: Ribonucleoprotein Complex Subunit Organization