EPH Receptor A8 anticorps (Internal Region)
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- Antigène Voir toutes EPH Receptor A8 (EPHA8) Anticorps
- EPH Receptor A8 (EPHA8)
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Épitope
- Internal Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp EPH Receptor A8 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- EPHA8 Antibody detects endogenous levels of total EPHA8.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human EPHA8, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product EPHA8 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- EPH Receptor A8 (EPHA8)
- Autre désignation
- EPHA8 (EPHA8 Produits)
- Synonymes
- anticorps TK, anticorps tke17-a, anticorps si:ch211-122l14.1, anticorps EPHA8, anticorps EEK, anticorps EK3, anticorps HEK3, anticorps AW047546, anticorps Eek, anticorps Hek3, anticorps mKIAA1459, anticorps EPH receptor A8 L homeolog, anticorps EPH receptor A8, anticorps eph receptor A8, anticorps Eph receptor A8, anticorps epha8.L, anticorps EPHA8, anticorps epha8, anticorps Epha8
- Sujet
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Description: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity).
Gene: EPHA8
- Poids moléculaire
- 111kDa.
- ID gène
- 2046
- UniProt
- P29322
- Pathways
- Signalisation RTK
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