ERAP1 anticorps (Internal Region)
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- Antigène Voir toutes ERAP1 Anticorps
- ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))
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Épitope
- Internal Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ERAP1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- ERAP1 Antibody detects endogenous levels of total ERAP1.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human ERAP1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product ERAP1 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- ERAP1 (Endoplasmic Reticulum Aminopeptidase 1 (ERAP1))
- Autre désignation
- ERAP1 (ERAP1 Produits)
- Synonymes
- anticorps MGC166160, anticorps DKFZp469C044, anticorps ARTS-1, anticorps A-LAP, anticorps ALAP, anticorps APPILS, anticorps ARTS1, anticorps ERAAP, anticorps ERAAP1, anticorps PILS-AP, anticorps PILSAP, anticorps Arts1, anticorps PILSA, anticorps Appils, anticorps endoplasmic reticulum aminopeptidase 1, anticorps endoplasmic reticulum aminopeptidase 1b, anticorps ERAP1, anticorps erap1, anticorps erap1b, anticorps Erap1
- Sujet
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Description: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Gene: ERAP1
- Poids moléculaire
- 107 kDa
- ID gène
- 51752
- UniProt
- Q9NZ08
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