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FOXN1 anticorps (N-Term)

FOXN1 Reactivité: Humain, Rat WB, ELISA, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6261798
  • Antigène Voir toutes FOXN1 Anticorps
    FOXN1 (Forkhead Box N1 (FOXN1))
    Épitope
    • 16
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 43
    • 19
    • 19
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat
    Hôte
    • 42
    • 1
    Lapin
    Clonalité
    • 43
    Polyclonal
    Conjugué
    • 13
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FOXN1 est non-conjugé
    Application
    • 32
    • 22
    • 16
    • 13
    • 13
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    FOXN1 Antibody detects endogenous levels of total FOXN1.
    Homologie
    Pig,Bovine,Horse,Rabbit
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human FOXN1, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product FOXN1 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    FOXN1 (Forkhead Box N1 (FOXN1))
    Autre désignation
    FOXN1 (FOXN1 Produits)
    Synonymes
    anticorps nude, anticorps whnb, anticorps FOXN1, anticorps foxN1, anticorps foxN, anticorps foxn1, anticorps FKHL20, anticorps RONU, anticorps WHN, anticorps D11Bhm185e, anticorps Fkh19, anticorps HFH-11, anticorps Hfh11, anticorps Whn, anticorps nu, anticorps Rnu, anticorps forkhead box N1, anticorps forkhead box protein N1, anticorps FOXN1, anticorps foxn1, anticorps foxN1, anticorps LOC100125524, anticorps Foxn1
    Sujet

    Description: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891).

    Gene: FOXN1

    Poids moléculaire
    69kDa
    ID gène
    8456
    UniProt
    O15353
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