HBXIP anticorps (Internal Region)
-
- Antigène Voir toutes HBXIP Anticorps
- HBXIP (Hepatitis B Virus X-Interacting Protein (HBXIP))
-
Épitope
- Internal Region
- Reactivité
- Humain, Souris, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp HBXIP est non-conjugé
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- HBXIP Antibody detects endogenous levels of total HBXIP.
- Homologie
- Pig,Bovine,Horse,Rabbit,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human HBXIP, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product HBXIP Anticorps primaire
-
-
- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
-
- Antigène
- HBXIP (Hepatitis B Virus X-Interacting Protein (HBXIP))
- Autre désignation
- LAMTOR5 (HBXIP Produits)
- Synonymes
- anticorps HBXIP, anticorps xip, anticorps XIP, anticorps 1110003H18Rik, anticorps Hbxip, anticorps late endosomal/lysosomal adaptor, MAPK and MTOR activator 5, anticorps Hepatitis B virus X-interacting protein, anticorps LAMTOR5, anticorps xip, anticorps Lamtor5
- Classe de substances
- Viral Protein
- Sujet
-
Description: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.
Gene: LAMTOR5
- Poids moléculaire
- 22 kDa
- ID gène
- 10542
- UniProt
- O43504
- Pathways
- Signalisation PI3K-Akt, Regulation of Cell Size
-