HIPK1 anticorps (N-Term)

N° du produit ABIN6262240

Détail du produit anti-HIPK1 anticorps

Antigène: HIPK1 (Homeodomain Interacting Protein Kinase 1 (HIPK1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIPK1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: HIPK1 Antibody detects endogenous levels of total HIPK1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human HIPK1, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur HIPK1

Antigène: HIPK1 (Homeodomain Interacting Protein Kinase 1 (HIPK1))

Autre désignation: HIPK1 (HIPK1 Produits)

Synonymes: anticorps HIPK1, anticorps myak, anticorps nbak2, anticorps hipk1, anticorps Myak, anticorps Nbak2, anticorps 1110062K04Rik, anticorps homeodomain interacting protein kinase 1, anticorps homeodomain interacting protein kinase 1 L homeolog, anticorps homeodomain interacting protein kinase 1 S homeolog, anticorps HIPK1, anticorps hipk1.L, anticorps hipk1, anticorps hipk1.S, anticorps Hipk1

Sujet:

Description: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

Gene: HIPK1

Poids moléculaire: 131 kDa

ID gène: 204851

UniProt: Q86Z02