HNRNPA2B1 anticorps (N-Term)

N° du produit ABIN6262328

Détail du produit anti-HNRNPA2B1 anticorps

Antigène: HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNRNPA2B1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: HnRNP A2/B1 Antibody detects endogenous levels of total hnRNP A2/B1.

Homologie: Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human hnRNP A2/B1, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur HNRNPA2B1

Antigène: HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1))

Autre désignation: HNRNPA2B1 (HNRNPA2B1 Produits)

Synonymes: anticorps HNRNPA2, anticorps HNRNPB1, anticorps HNRPA2, anticorps HNRPA2B1, anticorps HNRPB1, anticorps RNPA2, anticorps SNRPB1, anticorps hnrpa2b1, anticorps MGC53135, anticorps HNRNPA2B1, anticorps hnrnpa2, anticorps hnrnpb1, anticorps hnrpa2, anticorps hnrpb1, anticorps rnpa2, anticorps snrpb1, anticorps 9130414A06Rik, anticorps Hnrpa2, anticorps Hnrpa2b1, anticorps hnrnp-A, anticorps hnRNP, anticorps heterogeneous nuclear ribonucleoprotein A2/B1, anticorps heterogeneous nuclear ribonucleoprotein A2/B1 S homeolog, anticorps heterogeneous nuclear ribonucleoproteins A2/B1, anticorps HNRNPA2B1, anticorps hnrnpa2b1.S, anticorps hnrnpa2b1, anticorps Hnrnpa2b1, anticorps LOC100353281

Sujet:

Description: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).

Gene: HNRNPA2B1

Poids moléculaire: 37kDa

ID gène: 3181

UniProt: P22626