Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

HUS1 anticorps (Internal Region)

HUS1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6262423
  • Antigène Voir toutes HUS1 Anticorps
    HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))
    Épitope
    • 15
    • 8
    • 7
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 62
    • 4
    Lapin
    Clonalité
    • 65
    • 1
    Polyclonal
    Conjugué
    • 23
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HUS1 est non-conjugé
    Application
    • 31
    • 26
    • 13
    • 13
    • 9
    • 8
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    HUS1 Antibody detects endogenous levels of total HUS1.
    Homologie
    Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human HUS1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product HUS1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))
    Autre désignation
    HUS1 (HUS1 Produits)
    Synonymes
    anticorps hHUS1, anticorps mHus1, anticorps XHus1, anticorps hus1, anticorps HUS1 checkpoint clamp component, anticorps checkpoint clamp complex protein Hus1, anticorps HUS1 checkpoint clamp component L homeolog, anticorps HUS1, anticorps Hus1, anticorps hus1, anticorps hus1.L
    Sujet

    Description: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds, endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths, and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.

    Gene: HUS1

    Poids moléculaire
    31kDa
    ID gène
    3364
    UniProt
    O60921
Vous êtes ici:
Support technique