EIF3L anticorps (N-Term)

N° du produit ABIN6262447

Détail du produit anti-EIF3L anticorps

Antigène: EIF3L (Eukaryotic Translation Initiation Factor 3, Subunit L (EIF3L))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF3L est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: IF3EI Antibody detects endogenous levels of total IF3EI.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human IF3EI, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur EIF3L

Antigène: EIF3L (Eukaryotic Translation Initiation Factor 3, Subunit L (EIF3L))

Autre désignation: EIF3L (EIF3L Produits)

Synonymes: anticorps wu:fb66c05, anticorps zgc:64147, anticorps EIF3EIP, anticorps EIF3S11, anticorps EIF3S6IP, anticorps HSPC021, anticorps HSPC025, anticorps MSTP005, anticorps 0610011H21Rik, anticorps D15N1e, anticorps Eif3eip, anticorps Eif3ip, anticorps Eif3s6ip, anticorps HSP-66Y, anticorps PAF67, anticorps eif3eip, anticorps eif3s6ip, anticorps eukaryotic translation initiation factor 3, subunit 6 interacting protein, anticorps eukaryotic translation initiation factor 3 subunit L, anticorps eukaryotic translation initiation factor 3, subunit L, anticorps eukaryotic translation initiation factor 3 subunit L L homeolog, anticorps eif3s6ip, anticorps EIF3L, anticorps Eif3l, anticorps eif3l.L

Sujet:

Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene: EIF3L

Poids moléculaire: 67kDa

ID gène: 51386

UniProt: Q9Y262

Pathways: Ribonucleoprotein Complex Subunit Organization