IFT57 anticorps (Internal Region)

N° du produit ABIN6262481

Détail du produit anti-IFT57 anticorps

Antigène: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFT57 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: IFT57 Antibody detects endogenous levels of total IFT57.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human IFT57, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur IFT57

Antigène: IFT57 (Intraflagellar Transport 57 Homolog (IFT57))

Autre désignation: IFT57 (IFT57 Produits)

Synonymes: anticorps Esrrbl1, anticorps 4833420A15Rik, anticorps Hippi, anticorps MHS4R2, anticorps ESRRBL1, anticorps HIPPI, anticorps intraflagellar transport 57, anticorps intraflagellar transport 57 S homeolog, anticorps Ift57, anticorps IFT57, anticorps ift57.S

Sujet:

Description: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear.

Gene: IFT57

Poids moléculaire: 49 kDa

ID gène: 55081

UniProt: Q9NWB7

Pathways: Signalisation Hedgehog, Positive Regulation of Endopeptidase Activity