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Interleukin enhancer-binding factor 3 (ILF3) (Internal Region) anticorps

ILF3 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6262571
  • Antigène Voir toutes Interleukin enhancer-binding factor 3 (ILF3) Anticorps
    Interleukin enhancer-binding factor 3 (ILF3)
    Épitope
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 57
    • 38
    • 34
    • 13
    • 11
    • 11
    • 10
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 52
    • 3
    • 1
    Lapin
    Clonalité
    • 45
    • 12
    Polyclonal
    Conjugué
    • 43
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Inconjugué
    Application
    • 36
    • 16
    • 10
    • 10
    • 9
    • 9
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    ILF3 Antibody detects endogenous levels of total ILF3.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human ILF3, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product ILF3 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    Interleukin enhancer-binding factor 3 (ILF3)
    Autre désignation
    ILF3 (ILF3 Produits)
    Sujet

    Description: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 Molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552).

    Gene: ILF3

    Poids moléculaire
    95kDa
    ID gène
    3609
    UniProt
    Q12906
    Pathways
    M Phase
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