NOS2 anticorps (C-Term)

N° du produit ABIN6262590

Détail du produit anti-NOS2 anticorps

Antigène: NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOS2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: INOS Antibody detects endogenous levels of total iNOS.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human iNOS, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NOS2

Antigène: NOS2 (Nitric Oxide Synthase 2, Inducible (NOS2))

Autre désignation: NOS2 (NOS2 Produits)

Synonymes: anticorps HEP-NOS, anticorps INOS, anticorps NOS, anticorps NOS2A, anticorps NOS-II, anticorps Nos-2, anticorps Nos2a, anticorps i-NOS, anticorps iNOS, anticorps iNos, anticorps NOS2a, anticorps NOS2, anticorps BmNOS2, anticorps Nsl, anticorps nos2, anticorps nitric oxide synthase 2, anticorps nitric oxide synthase 2, inducible, anticorps inducible nitric oxide synthase, anticorps inducible nitric-oxide synthase, anticorps nanos C2HC-type zinc finger 2, anticorps NOS2, anticorps Nos2, anticorps nos2, anticorps LOC396821, anticorps NANOS2

Sujet:

Description: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7531687, PubMed:7544004). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8 (PubMed:19688109).

Gene: NOS2

Poids moléculaire: 130kDa

ID gène: 4843

UniProt: P35228

Pathways: Retinoic Acid Receptor Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Inositol Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process