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INSIG1 anticorps (Internal Region)

INSIG1 Reactivité: Humain, Souris WB, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6262599
  • Antigène Voir toutes INSIG1 Anticorps
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Épitope
    • 7
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 28
    • 8
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris
    Hôte
    • 28
    Lapin
    Clonalité
    • 28
    Polyclonal
    Conjugué
    • 16
    • 4
    • 2
    • 2
    • 2
    • 2
    Cet anticorp INSIG1 est non-conjugé
    Application
    • 24
    • 17
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    INSIG1 Antibody detects endogenous levels of total INSIG1.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human INSIG1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product INSIG1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Autre désignation
    INSIG1 (INSIG1 Produits)
    Synonymes
    anticorps cl-6, anticorps cl6, anticorps CL-6, anticorps CL6, anticorps fb55a03, anticorps fi35b10, anticorps wu:fb55a03, anticorps wu:fi35b10, anticorps zgc:55439, anticorps 1810013C12Rik, anticorps Insig-1, anticorps INSIG-1, anticorps insulin induced gene 1, anticorps insulin induced gene 1 L homeolog, anticorps INSIG1, anticorps insig1, anticorps insig1.L, anticorps Insig1
    Sujet

    Description: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

    Gene: INSIG1

    Poids moléculaire
    28-31, 66-70 kDa
    ID gène
    3638
    UniProt
    O15503
    Pathways
    ER-Nucleus Signaling
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