INSIG2 anticorps (N-Term)

N° du produit ABIN6262600

Détail du produit anti-INSIG2 anticorps

Antigène: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INSIG2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: INSIG2 Antibody detects endogenous levels of total INSIG2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human INSIG2, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur INSIG2

Antigène: INSIG2 (Insulin Induced Gene 2 (INSIG2))

Autre désignation: INSIG2 (INSIG2 Produits)

Synonymes: anticorps MGC82156, anticorps INSIG-2, anticorps 2900053I11Rik, anticorps C730043J18Rik, anticorps Insig-2, anticorps insulin induced gene 2, anticorps insulin induced gene 2 L homeolog, anticorps insig2, anticorps insig2.L, anticorps INSIG2, anticorps Insig2

Sujet:

Description: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.

Gene: INSIG2

Poids moléculaire: 25 kDa

ID gène: 51141

UniProt: Q9Y5U4

Pathways: ER-Nucleus Signaling