FERMT2 anticorps (C-Term)

N° du produit ABIN6262815

Détail du produit anti-FERMT2 anticorps

Antigène: FERMT2 (Fermitin Family Member 2 (FERMT2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FERMT2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Kindlin 2 Antibody detects endogenous levels of total Kindlin 2.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Kindlin 2, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur FERMT2

Antigène: FERMT2 (Fermitin Family Member 2 (FERMT2))

Autre désignation: FERMT2 (FERMT2 Produits)

Synonymes: anticorps AA960555, anticorps Kindlin-2, anticorps Mig2, anticorps Plekhc1, anticorps KIND2, anticorps MIG2, anticorps PLEKHC1, anticorps UNC112, anticorps UNC112B, anticorps mig-2, anticorps fermitin family member 2, anticorps Fermt2, anticorps FERMT2

Sujet:

Description: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading, this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.

Gene: FERMT2

Poids moléculaire: 78 kDa

ID gène: 10979

UniProt: Q96AC1

Pathways: Cell-Cell Junction Organization