KLHL3 anticorps (N-Term)
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- Antigène Voir toutes KLHL3 Anticorps
- KLHL3 (Kelch-Like 3 (KLHL3))
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Épitope
- N-Term
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KLHL3 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- KLHL3 Antibody detects endogenous levels of total KLHL3.
- Homologie
- Bovine,Horse,Sheep,Rabbit
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human KLHL3, corresponding to a region within N-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product KLHL3 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- KLHL3 (Kelch-Like 3 (KLHL3))
- Autre désignation
- KLHL3 (KLHL3 Produits)
- Synonymes
- anticorps 7530408C15Rik, anticorps AI430941, anticorps EG627648, anticorps PHA2D, anticorps RGD1565218, anticorps kelch like family member 3, anticorps kelch-like 3, anticorps kelch-like family member 3, anticorps KLHL3, anticorps Klhl3
- Sujet
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Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity).
Gene: KLHL3
- Poids moléculaire
- 64 kDa
- ID gène
- 26249
- UniProt
- Q9UH77
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