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KLHL3 anticorps (N-Term)

KLHL3 Reactivité: Humain, Souris WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6262847
  • Antigène Voir toutes KLHL3 Anticorps
    KLHL3 (Kelch-Like 3 (KLHL3))
    Épitope
    • 15
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 55
    • 8
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 53
    • 2
    Lapin
    Clonalité
    • 55
    Polyclonal
    Conjugué
    • 21
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp KLHL3 est non-conjugé
    Application
    • 43
    • 23
    • 13
    • 13
    • 7
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    KLHL3 Antibody detects endogenous levels of total KLHL3.
    Homologie
    Bovine,Horse,Sheep,Rabbit
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human KLHL3, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product KLHL3 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    KLHL3 (Kelch-Like 3 (KLHL3))
    Autre désignation
    KLHL3 (KLHL3 Produits)
    Synonymes
    anticorps 7530408C15Rik, anticorps AI430941, anticorps EG627648, anticorps PHA2D, anticorps RGD1565218, anticorps kelch like family member 3, anticorps kelch-like 3, anticorps kelch-like family member 3, anticorps KLHL3, anticorps Klhl3
    Sujet

    Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity).

    Gene: KLHL3

    Poids moléculaire
    64 kDa
    ID gène
    26249
    UniProt
    Q9UH77
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