LRP4 anticorps (N-Term)

N° du produit ABIN6263007

Détail du produit anti-LRP4 anticorps

Antigène: LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: LRP4 Antibody detects endogenous levels of total LRP4.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human LRP4, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur LRP4

Antigène: LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))

Autre désignation: LRP4 (LRP4 Produits)

Synonymes: anticorps CLSS, anticorps LRP-4, anticorps LRP10, anticorps MEGF7, anticorps SOST2, anticorps Megf7, anticorps 6430526J12Rik, anticorps D230026E03, anticorps mdig, anticorps LRP4, anticorps lrp10, anticorps megf7, anticorps LDL receptor related protein 4, anticorps low density lipoprotein receptor-related protein 4, anticorps LRP4, anticorps Lrp4, anticorps lrp4

Sujet:

Description: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).

Gene: LRP4

Poids moléculaire: 212kDa

ID gène: 4038

UniProt: O75096

Pathways: Skeletal Muscle Fiber Development