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MAD2L2 anticorps (Internal Region)

MAD2L2 Reactivité: Humain, Souris, Rat WB, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6263049
  • Antigène Voir toutes MAD2L2 Anticorps
    MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))
    Épitope
    • 15
    • 9
    • 4
    • 2
    • 1
    • 1
    Internal Region
    Reactivité
    • 41
    • 12
    • 10
    • 1
    Humain, Souris, Rat
    Hôte
    • 40
    • 3
    Lapin
    Clonalité
    • 32
    • 11
    Polyclonal
    Conjugué
    • 18
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MAD2L2 est non-conjugé
    Application
    • 31
    • 14
    • 14
    • 13
    • 8
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    MAD2L2 Antibody detects endogenous levels of total MAD2L2.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human MAD2L2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MAD2L2 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    MAD2L2 (MAD2 Mitotic Arrest Deficient-Like 2 (MAD2L2))
    Autre désignation
    MAD2L2 (MAD2L2 Produits)
    Synonymes
    anticorps mad2b, anticorps 2310033C13Rik, anticorps MAD2B, anticorps REV7, anticorps mad2B, anticorps mad2l2-A, anticorps xMAD2L2, anticorps POLZ2, anticorps mad2l2, anticorps zgc:110299, anticorps mitotic arrest deficient 2 like 2, anticorps MAD2 mitotic arrest deficient-like 2, anticorps mitotic arrest deficient 2 like 2 S homeolog, anticorps MAD2 mitotic arrest deficient-like 2 (yeast), anticorps si:dkey-23c22.2, anticorps mad2l2, anticorps MAD2L2, anticorps Mad2l2, anticorps mad2l2.S, anticorps si:dkey-23c22.2
    Sujet

    Description: Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation.

    Gene: MAD2L2

    Poids moléculaire
    24 kDa
    ID gène
    10459
    UniProt
    Q9UI95
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