DIAPH1 anticorps

N° du produit ABIN6263174

Détail du produit anti-DIAPH1 anticorps

Antigène: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIAPH1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: MDia1 antibody detects endogenous levels of mDia1.

Réactivité croisée: Humain, Singe, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human mDia1.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur DIAPH1

Antigène: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Autre désignation: mDia1 (DIAPH1 Produits)

Synonymes: anticorps DIAPH1, anticorps dia1, anticorps drf1, anticorps dfna1, anticorps diap1, anticorps lfhl1, anticorps DIAPH2, anticorps Diap1, anticorps D18Wsu154e, anticorps Dia1, anticorps Diaph1, anticorps Drf1, anticorps mKIAA4062, anticorps p140mDia, anticorps DFNA1, anticorps DIA1, anticorps DRF1, anticorps LFHL1, anticorps hDIA1, anticorps diaphanous related formin 1, anticorps diaphanous related formin 2, anticorps diaphanous-related formin 1, anticorps protein diaphanous homolog 1, anticorps DIAPH1, anticorps diaph1, anticorps DIAPH2, anticorps Diaph1, anticorps LOC100457442

Sujet:

Description: Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854, PubMed:21834987). Plays a role in brain development (PubMed:24781755).

Gene: DIAPH1

Poids moléculaire: 140-150, 70 kDa

ID gène: 1729

UniProt: O60610

Pathways: Sensory Perception of Sound