CDC42BPB anticorps (C-Term)
-
- Antigène Voir toutes CDC42BPB Anticorps
- CDC42BPB (CDC42 Binding Protein Kinase beta (DMPK-Like) (CDC42BPB))
-
Épitope
- C-Term
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp CDC42BPB est non-conjugé
- Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- MRCKbeta Antibody detects endogenous levels of total MRCKbeta.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human MRCKbeta, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product CDC42BPB Anticorps primaire
-
-
- Indications d'application
- WB 1:1000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
-
- Antigène
- CDC42BPB (CDC42 Binding Protein Kinase beta (DMPK-Like) (CDC42BPB))
- Autre désignation
- CDC42BPB (CDC42BPB Produits)
- Sujet
-
Description: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity).
Gene: CDC42BPB
- Poids moléculaire
- 194kDa
- ID gène
- 9578
- UniProt
- Q9Y5S2
-