Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

Myogenin anticorps (C-Term)

MYOG Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6263489
  • Antigène Voir toutes Myogenin (MYOG) Anticorps
    Myogenin (MYOG) (Myogenin (Myogenic Factor 4) (MYOG))
    Épitope
    • 31
    • 15
    • 15
    • 12
    • 12
    • 10
    • 9
    • 8
    • 8
    • 7
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 114
    • 85
    • 58
    • 40
    • 29
    • 14
    • 13
    • 12
    Humain, Souris, Rat
    Hôte
    • 72
    • 60
    • 1
    Lapin
    Clonalité
    • 72
    • 61
    Polyclonal
    Conjugué
    • 61
    • 10
    • 10
    • 9
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Myogenin est non-conjugé
    Application
    • 97
    • 73
    • 34
    • 30
    • 30
    • 20
    • 13
    • 13
    • 11
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificité
    MYOG Antibody detects endogenous levels of total MYOG.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human MYOG, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product MYOG Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    Myogenin (MYOG) (Myogenin (Myogenic Factor 4) (MYOG))
    Autre désignation
    MYOG (MYOG Produits)
    Synonymes
    anticorps cb553, anticorps zgc:100763, anticorps LOC446037, anticorps myf4, anticorps Xmyog, anticorps myogenin, anticorps LOC100136471, anticorps LOC100224062, anticorps LOC100303673, anticorps MYF4, anticorps bHLHc3, anticorps myo, anticorps myf-4, anticorps myogenin, anticorps myogenin (myogenic factor 4), anticorps MYOG, anticorps myog, anticorps LOC100303673, anticorps Myog
    Sujet

    Description: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth, phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).

    Gene: MYOG

    Poids moléculaire
    25 kDa
    ID gène
    4656
    UniProt
    P15173
    Pathways
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
Vous êtes ici:
Support technique