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Nicastrin anticorps (C-Term)

NCSTN Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6263547
  • Antigène Voir toutes Nicastrin (NCSTN) Anticorps
    Nicastrin (NCSTN)
    Épitope
    • 15
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 37
    • 32
    • 21
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 50
    • 3
    Lapin
    Clonalité
    • 42
    • 11
    Polyclonal
    Conjugué
    • 21
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Nicastrin est non-conjugé
    Application
    • 39
    • 13
    • 13
    • 8
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    NCSTN Antibody detects endogenous levels of total NCSTN.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human NCSTN, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product NCSTN Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    Nicastrin (NCSTN)
    Autre désignation
    NCSTN (NCSTN Produits)
    Sujet

    Description: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

    Gene: NCSTN

    Poids moléculaire
    77kDa
    ID gène
    23385
    UniProt
    Q92542
    Pathways
    Signalisation Notch, Neurotrophin Signaling Pathway
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