Norrie Disease (Pseudoglioma) anticorps

N° du produit ABIN6263552

Détail du produit anti-Norrie Disease (Pseudoglioma) anticorps

Antigène: Norrie Disease (Pseudoglioma) (NDP)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Norrie Disease (Pseudoglioma) est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: NDP Antibody detects endogenous levels of total NDP

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NDP

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur Norrie Disease (Pseudoglioma)

Antigène: Norrie Disease (Pseudoglioma) (NDP)

Autre désignation: NDP (NDP Produits)

Synonymes: anticorps EVR2, anticorps FEVR, anticorps ND, anticorps evr2, anticorps fevr, anticorps xnorrin, anticorps Ndph, anticorps RGD1563968, anticorps NDP, norrin cystine knot growth factor, anticorps Norrie disease (pseudoglioma) L homeolog, anticorps Norrie disease (pseudoglioma) (human), anticorps NDP, anticorps ndp.L, anticorps Ndp

Sujet:

Description: Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.

Gene: NDP

Poids moléculaire: 15kDa

ID gène: 4693

UniProt: Q00604

Pathways: Sensory Perception of Sound