OAS1 anticorps (C-Term)

N° du produit ABIN6263786

Détail du produit anti-OAS1 anticorps

Antigène: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OAS1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: OAS1 Antibody detects endogenous levels of total OAS1.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human OAS1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur OAS1

Antigène: OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))

Autre désignation: OAS1 (OAS1 Produits)

Synonymes: anticorps OAS1, anticorps IFI-4, anticorps OIAS, anticorps OIASI, anticorps L3, anticorps Pp2a2, anticorps 2',5'-oligoadenylate synthetase 1, anticorps 2'-5'-oligoadenylate synthetase 1, anticorps 2'-5' oligoadenylate synthetase 1A, anticorps protein phosphatase 2 catalytic subunit beta, anticorps OAS1, anticorps Oas1a, anticorps Ppp2cb, anticorps Oas1

Sujet:

Description: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

Gene: OAS1

Poids moléculaire: 46 kDa

ID gène: 4938

UniProt: P00973

Pathways: Hepatitis C