p63 anticorps (C-Term)

N° du produit ABIN6263986

Détail du produit anti-p63 anticorps

Antigène: p63 (TP63) (Tumor Protein P63 (TP63))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p63 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: P63 Antibody detects endogenous levels of total p63.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human p63, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur p63

Antigène: p63 (TP63) (Tumor Protein P63 (TP63))

Autre désignation: TP63 (TP63 Produits)

Synonymes: anticorps AIS, anticorps B(p51A), anticorps B(p51B), anticorps EEC3, anticorps KET, anticorps LMS, anticorps NBP, anticorps OFC8, anticorps RHS, anticorps SHFM4, anticorps TP53CP, anticorps TP53L, anticorps TP73L, anticorps p40, anticorps p51, anticorps p53CP, anticorps p63, anticorps p73H, anticorps p73L, anticorps TP63, anticorps tp63, anticorps DNp63, anticorps id:ibd3516, anticorps tp73l, anticorps wu:fc89f04, anticorps wu:fk85h07, anticorps wu:fk88b02, anticorps Ket, anticorps P73l, anticorps Tp73l, anticorps Trp63, anticorps TRP63, anticorps AI462811, anticorps P51/P63, anticorps P63, anticorps Tp63, anticorps Trp53rp1, anticorps Xp63, anticorps ket, anticorps np63, anticorps tp73l-A, anticorps trp63, anticorps tumor protein p63, anticorps transformation related protein 63, anticorps tumor protein p63 L homeolog, anticorps TP63, anticorps tp63, anticorps Tp63, anticorps Trp63, anticorps tp63.L

Sujet:

Description: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.

Gene: TP63

Poids moléculaire: 77kDa

ID gène: 8626

UniProt: Q9H3D4