PHF19 anticorps (Internal Region)
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- Antigène Voir toutes PHF19 Anticorps
- PHF19 (PHD Finger Protein 19 (PHF19))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PHF19 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- PHF19 Antibody detects endogenous levels of total PHF19.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human PHF19, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PHF19 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- PHF19 (PHD Finger Protein 19 (PHF19))
- Autre désignation
- PHF19 (PHF19 Produits)
- Synonymes
- anticorps si:dkeyp-51b7.1, anticorps pcl3, anticorps MGC147603, anticorps MTF2L1, anticorps PCL3, anticorps TDRD19B, anticorps 3110009G19Rik, anticorps 3321402G02Rik, anticorps PHD finger protein 19, anticorps Phf19, anticorps PHF19, anticorps phf19
- Sujet
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Description: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
Gene: PHF19
- Poids moléculaire
- 66 kDa
- ID gène
- 26147
- UniProt
- Q5T6S3
- Pathways
- Stem Cell Maintenance
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