PITX3 anticorps
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- Antigène Voir toutes PITX3 Anticorps
- PITX3 (Pituitary Homeobox 3 (PITX3))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PITX3 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- PITX3 Antibody detects endogenous levels of total PITX3
- Réactivité croisée
- Humain, Souris, Rat (Rattus)
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human PITX3
- Isotype
- IgG
- Top Product
- Discover our top product PITX3 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000 IHC 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C.Stable for 12 months from date of receipt
- Date de péremption
- 12 months
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- Antigène
- PITX3 (Pituitary Homeobox 3 (PITX3))
- Autre désignation
- PITX3 (PITX3 Produits)
- Synonymes
- anticorps CTPP4, anticorps CTRCT11, anticorps PTX3, anticorps pitx3, anticorps Ptx3, anticorps ak, anticorps zgc:109716, anticorps pitx3-A, anticorps xPitx3, anticorps paired like homeodomain 3, anticorps paired-like homeodomain 3, anticorps paired like homeodomain 3 L homeolog, anticorps paired-like homeodomain transcription factor 3, anticorps paired-like homeodomain transcription factor Pitx3, anticorps PITX3, anticorps Pitx3, anticorps pitx3.L, anticorps pitx3
- Sujet
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Description: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).
Gene: PITX3
- Poids moléculaire
- 32 kDa
- ID gène
- 5309
- UniProt
- O75364
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