Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

PNPT1 anticorps (C-Term)

PNPT1 Reactivité: Humain, Souris WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6264324
  • Antigène Voir toutes PNPT1 Anticorps
    PNPT1 (Polyribonucleotide Nucleotidyltransferase 1 (PNPT1))
    Épitope
    • 15
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 41
    • 21
    • 19
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris
    Hôte
    • 55
    • 3
    Lapin
    Clonalité
    • 57
    • 1
    Polyclonal
    Conjugué
    • 26
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PNPT1 est non-conjugé
    Application
    • 49
    • 20
    • 13
    • 13
    • 11
    • 9
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    PNPase Antibody detects endogenous levels of total PNPase.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human PNPase, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PNPT1 Anticorps primaire
  • Indications d'application
    WB 1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    PNPT1 (Polyribonucleotide Nucleotidyltransferase 1 (PNPT1))
    Autre désignation
    PNPT1 (PNPT1 Produits)
    Synonymes
    anticorps COXPD13, anticorps DFNB70, anticorps OLD35, anticorps PNPASE, anticorps old-35, anticorps 1200003F12Rik, anticorps Old35, anticorps PNPase, anticorps Pnptl1, anticorps polyribonucleotide nucleotidyltransferase 1, mitochondrial, anticorps polyribonucleotide nucleotidyltransferase 1, anticorps CpipJ_CPIJ005886, anticorps PNPT1, anticorps Pnpt1
    Sujet

    Description: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration, regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity, degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells, specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.

    Gene: PNPT1

    Poids moléculaire
    85kDa
    ID gène
    87178
    UniProt
    Q8TCS8
Vous êtes ici:
Support technique