POLI anticorps (N-Term)
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- Antigène Voir toutes POLI Anticorps
- POLI (Polymerase (DNA Directed) iota (POLI))
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Épitope
- N-Term
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Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp POLI est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- POLI Antibody detects endogenous levels of total POLI.
- Homologie
- Rabbit
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human POLI, corresponding to a region within N-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product POLI Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- POLI (Polymerase (DNA Directed) iota (POLI))
- Autre désignation
- POLI (POLI Produits)
- Synonymes
- anticorps poli, anticorps wu:fc27h11, anticorps zgc:110185, anticorps GB12093, anticorps NV16187, anticorps RAD30B, anticorps RAD3OB, anticorps Rad30b, anticorps DNA polymerase iota, anticorps polymerase (DNA directed) iota, anticorps polymerase (DNA directed), iota, anticorps POLI, anticorps poli, anticorps LOC551219, anticorps AFUA_4G11140, anticorps LOC5568276, anticorps Pol-iota, anticorps Poli
- Sujet
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Description: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Gene: POLI
- Poids moléculaire
- 80kDa
- ID gène
- 11201
- UniProt
- Q9UNA4
- Pathways
- Réparation de l'ADN
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