PPP4C anticorps (C-Term)

N° du produit ABIN6264398

Détail du produit anti-PPP4C anticorps

Antigène: PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP4C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: PPP4C Antibody detects endogenous levels of total PPP4C.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PPP4C, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PPP4C

Antigène: PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))

Autre désignation: PPP4C (PPP4C Produits)

Synonymes: anticorps pp4, anticorps ppx, anticorps pp4c, anticorps pph3, anticorps MGC75928, anticorps PP4C-A, anticorps gc:56413, anticorps ppp4c, anticorps wu:fd05e08, anticorps zgc:56413, anticorps PP4, anticorps PP4C, anticorps PPH3, anticorps PPP4, anticorps PPX, anticorps 1110002D08Rik, anticorps AU016079, anticorps Ppx, anticorps protein phosphatase 4 catalytic subunit, anticorps protein phosphatase 4, catalytic subunit a, anticorps protein phosphatase 4, catalytic subunit, anticorps protein phosphatase 4 catalytic subunit S homeolog, anticorps ppp4c, anticorps ppp4ca, anticorps PPP4C, anticorps Ppp4c, anticorps ppp4c.S

Sujet:

Description: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Gene: PPP4C

Poids moléculaire: 35kDa

ID gène: 5531

UniProt: P60510