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PRC1 anticorps (Internal Region)

PRC1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6264405
  • Antigène Voir toutes PRC1 Anticorps
    PRC1 (Protein Regulator of Cytokinesis 1 (PRC1))
    Épitope
    • 8
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 22
    • 4
    Lapin
    Clonalité
    • 22
    • 4
    Polyclonal
    Conjugué
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp PRC1 est non-conjugé
    Application
    • 11
    • 6
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    PRC1 Antibody detects endogenous levels of total PRC1.
    Homologie
    Pig,Horse,Sheep,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human PRC1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PRC1 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IHC 1:200, IF/ICC, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    PRC1 (Protein Regulator of Cytokinesis 1 (PRC1))
    Autre désignation
    PRC1 (PRC1 Produits)
    Synonymes
    anticorps cb212, anticorps prc1, anticorps prc1l, anticorps zgc:55982, anticorps zgc:86918, anticorps MGC68845, anticorps zgc:55664, anticorps ase1, anticorps ASE1, anticorps D7Ertd348e, anticorps protein regulator of cytokinesis 1, anticorps protein regulator of cytokinesis 1a, anticorps protein regulator of cytokinesis 1 S homeolog, anticorps protein regulator of cytokinesis 1b, anticorps PRC1, anticorps prc1a, anticorps prc1.S, anticorps prc1b, anticorps CNC07120, anticorps prc1, anticorps Prc1
    Sujet

    Description: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436).

    Gene: PRC1

    Poids moléculaire
    72kDa
    ID gène
    9055
    UniProt
    O43663
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