PRMT1 anticorps (C-Term)

N° du produit ABIN6264433

Détail du produit anti-PRMT1 anticorps

Antigène: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRMT1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: PRMT1 Antibody detects endogenous levels of total PRMT1.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PRMT1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PRMT1

Antigène: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Autre désignation: PRMT1 (PRMT1 Produits)

Synonymes: anticorps ANM1, anticorps HCP1, anticorps HRMT1L2, anticorps IR1B4, anticorps 6720434D09Rik, anticorps AW214366, anticorps Hrmt1l2, anticorps Mrmt1, anticorps 3E10, anticorps anm1, anticorps hcp1, anticorps hrmt1l2, anticorps ir1b4, anticorps prmt1, anticorps prmt1b, anticorps xPRMT1b, anticorps xprmt1, anticorps xPRMT1, anticorps ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 1A, anticorps ATPRMT1A, anticorps F6F22.30, anticorps F6F22_30, anticorps protein arginine methyltransferase 1A, anticorps DDBDRAFT_0183976, anticorps DDBDRAFT_0235399, anticorps DDB_0183976, anticorps DDB_0235399, anticorps PRMT1, anticorps DKFZp459J1326, anticorps fb39h07, anticorps wu:fb39h07, anticorps zf1, anticorps zgc:66201, anticorps protein arginine methyltransferase 1, anticorps protein arginine N-methyltransferase 1, anticorps protein arginine methyltransferase 1 L homeolog, anticorps protein arginine methyltransferase 1 S homeolog, anticorps protein arginine methyltransferase 1A, anticorps protein arginine N-methyltransferase-1, anticorps protein arginine N-methyltransferase, anticorps protein arginine methyltransferase, anticorps PRMT1, anticorps Prmt1, anticorps prmt1.L, anticorps prmt1.S, anticorps PRMT1A, anticorps prm-1, anticorps EDI_007800, anticorps Smp_029240.3, anticorps prmt1

Sujet:

Description: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Gene: PRMT1

Poids moléculaire: 42kDa

ID gène: 3276

UniProt: Q99873