PTPN2 anticorps (C-Term)
-
- Antigène Voir toutes PTPN2 Anticorps
- PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
-
Épitope
- C-Term
-
Reactivité
- Humain, Rat, Souris
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp PTPN2 est non-conjugé
-
Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Specificité
- PTPN2 Antibody detects endogenous levels of total PTPN2.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human PTPN2, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PTPN2 Anticorps primaire
-
-
- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
-
- Antigène
- PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
- Autre désignation
- PTPN2 (PTPN2 Produits)
- Synonymes
- anticorps PTN2, anticorps PTPT, anticorps TC-PTP, anticorps TCELLPTP, anticorps TCPTP, anticorps AI325124, anticorps Ptpt, anticorps PTP-1B, anticorps cb806, anticorps ptpn2, anticorps ptpn2l, anticorps wu:fc10h07, anticorps zgc:55339, anticorps zgc:76973, anticorps hm:zeh1546, anticorps zgc:63623, anticorps ptn2, anticorps ptpt, anticorps tc-ptp, anticorps tcellptp, anticorps tcptp, anticorps protein tyrosine phosphatase, non-receptor type 2, anticorps protein tyrosine phosphatase, non-receptor type 2 S homeolog, anticorps protein tyrosine phosphatase, non-receptor type 2, b, anticorps protein tyrosine phosphatase, non-receptor type 2, a, anticorps protein tyrosine phosphatase, non-receptor type 2 L homeolog, anticorps PTPN2, anticorps Ptpn2, anticorps ptpn2.S, anticorps ptpn2b, anticorps ptpn2a, anticorps ptpn2.L
- Sujet
-
Description: Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA.
Gene: PTPN2
- Poids moléculaire
- 49kDa
- ID gène
- 5771
- UniProt
- P17706
- Pathways
- EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling
-