RAD21 anticorps (C-Term)

N° du produit ABIN6264613

Détail du produit anti-RAD21 anticorps

Antigène: RAD21 (RAD21 Homolog (RAD21))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD21 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Rad21 Antibody detects endogenous levels of total Rad21.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Rad21, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur RAD21

Antigène: RAD21 (RAD21 Homolog (RAD21))

Autre désignation: RAD21 (RAD21 Produits)

Synonymes: anticorps rad21, anticorps wu:fb55d02, anticorps wu:fb93f04, anticorps CDLS4, anticorps HR21, anticorps HRAD21, anticorps MCD1, anticorps NXP1, anticorps SCC1, anticorps hHR21, anticorps mKIAA0078, anticorps hr21, anticorps mcd1, anticorps nxp-1, anticorps nxp1, anticorps scc1, anticorps xrad21, anticorps RAD21 cohesin complex component, anticorps RAD21 cohesin complex component a, anticorps RAD21 cohesin complex component L homeolog, anticorps RAD21 cohesin complex component S homeolog, anticorps R-spondin 2, anticorps RAD21, anticorps rad21a, anticorps rad21.L, anticorps Rad21, anticorps rad21.S, anticorps RSPO2

Sujet:

Description: Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.

Gene: RAD21

Poids moléculaire: 130kDa

ID gène: 5885

UniProt: O60216

Pathways: Positive Regulation of Endopeptidase Activity