RAPGEF3 anticorps (C-Term)

N° du produit ABIN6264639

Détail du produit anti-RAPGEF3 anticorps

Antigène: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAPGEF3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Specificité: RAPGEF3 Antibody detects endogenous levels of total RAPGEF3.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human RAPGEF3, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur RAPGEF3

Antigène: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Autre désignation: RAPGEF3 (RAPGEF3 Produits)

Synonymes: anticorps RAPGEF3, anticorps epac, anticorps si:dkey-27m20.2, anticorps CAMP-GEFI, anticorps EPAC, anticorps EPAC1, anticorps HSU79275, anticorps bcm910, anticorps 2310016P22Rik, anticorps 9330170P05Rik, anticorps Epac, anticorps Epac1, anticorps Rap guanine nucleotide exchange factor 3, anticorps Rap guanine nucleotide exchange factor 3 S homeolog, anticorps Rap guanine nucleotide exchange factor (GEF) 3, anticorps RAPGEF3, anticorps rapgef3.S, anticorps rapgef3, anticorps Rapgef3

Sujet:

Description: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.

Gene: RAPGEF3

Poids moléculaire: 99kDa

ID gène: 10411

UniProt: O95398

Pathways: cAMP Metabolic Process