Raptor anticorps (C-Term)
-
- Antigène Voir toutes Raptor (RPTOR) Anticorps
- Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
-
Épitope
- C-Term
- Reactivité
- Humain, Souris, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp Raptor est non-conjugé
-
Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- Raptor Antibody detects endogenous levels of total Raptor.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human Raptor, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product RPTOR Anticorps primaire
-
-
- Indications d'application
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
-
- Antigène
- Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
- Autre désignation
- RPTOR (RPTOR Produits)
- Synonymes
- anticorps KOG1, anticorps Mip1, anticorps 4932417H02Rik, anticorps Rap, anticorps Raptor, anticorps mKIAA1303, anticorps RGD1311784, anticorps raptor, anticorps regulatory associated protein of MTOR complex 1, anticorps regulatory associated protein of MTOR, complex 1, anticorps regulatory associated protein of MTOR, complex 1 L homeolog, anticorps RPTOR, anticorps Rptor, anticorps rptor.L, anticorps rptor
- Sujet
-
Description: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals, functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.
Gene: RPTOR
- Poids moléculaire
- 149kDa
- ID gène
- 57521
- UniProt
- Q8N122
- Pathways
- Signalisation PI3K-Akt, Signalisation RTK, AMPK Signaling, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Autophagy, BCR Signaling, L'effet Warburg
-